ER-α + DES
ER-α + OHT ER-α + DES
ER-α + OHT
The DES-complex is Cartoons, colored cyan. H12A(colored magenta), NR Box II peptide binds to the AF site. The OHT-complex is Backbone, colored blue, H12B(colored magenta) occupies the AF II pocket. ERα-EST compared separately to the other ER LDB's ER-Ligand Color [PDB ID] Sequences of Colored Segments (Helix 12) A. ERa-EST Green [1ere.pdb] 231 KNVVPLYDLLLEMLDAHR 248 B. ERa-RAL Orange [1err.pdb] 235 ....PLYDLLLEMLDAH 247 C. ERa-OHT Red [3ert.pdb] 238 KNVVPLYDLLLEMLDAHRLHA 258 D. ERb-GEN Yellow [1qkm.pdb] 228 KNVVPVYDLLLEMLNAHVL 246 E. ERa-EST (mutant) Blue [1qkt.pdb] 228 KNVVPLYDLLLEMLDAHRLHA 248 F. ERa-EST (tetramer) Cyan [1a52.pdb] 235 KNVVPLYDLLLEML 248 ERα DNA Binding Domain complexed with DNA Dimer of the ERα DBD (residues 1-74) with bound DNA (ERE). The protein display is Backbone, colored Structure; the DNA is Sticks, colored CPK with a backbone "trace". The side chains of the Cys4 zinc finger motifs are Sticks, colored CPK; the four Zn ions are spacefill, colored dark red. The N- and C-termini of one subunit are labeled. ER-α + ESTradiol + Active site residues ER-α + DES + charge clamp residues
The DES-complex is Cartoons, colored cyan. H12A(colored magenta), NR Box II peptide binds to the AF site. The OHT-complex is Backbone, colored blue, H12B(colored magenta) occupies the AF II pocket.
ERα-EST compared separately to the other ER LDB's
ER-Ligand Color [PDB ID] Sequences of Colored Segments (Helix 12) A. ERa-EST Green [1ere.pdb] 231 KNVVPLYDLLLEMLDAHR 248 B. ERa-RAL Orange [1err.pdb] 235 ....PLYDLLLEMLDAH 247 C. ERa-OHT Red [3ert.pdb] 238 KNVVPLYDLLLEMLDAHRLHA 258 D. ERb-GEN Yellow [1qkm.pdb] 228 KNVVPVYDLLLEMLNAHVL 246 E. ERa-EST (mutant) Blue [1qkt.pdb] 228 KNVVPLYDLLLEMLDAHRLHA 248 F. ERa-EST (tetramer) Cyan [1a52.pdb] 235 KNVVPLYDLLLEML 248 ERα DNA Binding Domain complexed with DNA Dimer of the ERα DBD (residues 1-74) with bound DNA (ERE). The protein display is Backbone, colored Structure; the DNA is Sticks, colored CPK with a backbone "trace". The side chains of the Cys4 zinc finger motifs are Sticks, colored CPK; the four Zn ions are spacefill, colored dark red. The N- and C-termini of one subunit are labeled. ER-α + ESTradiol + Active site residues ER-α + DES + charge clamp residues
Dimer of the ERα DBD (residues 1-74) with bound DNA (ERE). The protein display is Backbone, colored Structure; the DNA is Sticks, colored CPK with a backbone "trace". The side chains of the Cys4 zinc finger motifs are Sticks, colored CPK; the four Zn ions are spacefill, colored dark red. The N- and C-termini of one subunit are labeled. ER-α + ESTradiol + Active site residues ER-α + DES + charge clamp residues
Dimer of the ERα DBD (residues 1-74) with bound DNA (ERE). The protein display is Backbone, colored Structure; the DNA is Sticks, colored CPK with a backbone "trace". The side chains of the Cys4 zinc finger motifs are Sticks, colored CPK; the four Zn ions are spacefill, colored dark red. The N- and C-termini of one subunit are labeled.