Multiple aliggnment of the ER-alpha receptor

Multiple alignment of the ERα receptor

* indicates positions which have a single, fully conserved residue
: indicates conservative differences
. less conservative differences

SWISS-PROT ID
Q9TV98|HORSE_____ ----MTMTLH TKASGMALLH QIQGNELETL NLPQFKIPLE RPLGEVYVES S------KPP
Q29040|PIG_______ ----MTMTLH TKASGMALLH QIQANELEPL NRPQLKIPLE RPLGEVYVDS S------KPA
P03372|HUMAN_____ ----MTMTLH TKASGMALLH QIQGNELEPL NRPQLKIPLE RPLGEVYLDS S------KPA
P19785|MOUSE_____ ----MTMTLH TKASGMALLH QIQGNELEPL NRPQLKMPME RALGEVYVDN S------KPT
P06211|RAT_______ ----MTMTLH TKASGMALLH QIQGNELEPL NRPQLKMPME RALGEVYVDN S------KPA
Q9QZJ5|G.HAMPSTER ----MTMTLH TKASGMALLH QIQGNELEPL SRPQLKMPLE RALSEVYVDS S------KPA
P06212|CHICK_____ ----MTMTLH TKASGVTLLH QIQGTELETL SRPQLKIPLE RSLSDMYVES N------KTG
Q91250|Z.FINCH___ ------MTLH TKTSGVTLLH QIQGTELETL SRPQLKIPLE RSLSDMYVET N------KTG
P81559|XENOPUS___ ----MTMPLP NKTTGVTFLH QIQSSELETL TRPPLKISLE RPLGEMYVEN N------RTG
Q9YHZ7|CATFISH___ --MSEEQARA EAPAGARQRR RSELEG---- ---YSVSLAS LKLSPMYPEE EQRTTGGISS
P57717|ZEBRAFISH_ ---------- ---------- ---------- ---------- -----MYPKE E-HSAGGISS
Q9PVZ9|G.SEABREAM ---------- ---------- ---------- ---------- -----MYPED S-RVSGGVAT
O42132|R.SEABREAM ---------- ---------- ---------- ---------- -----MYPED S-RGSGGVAT
P50240|I.TILAPIA_ ---------- ---------- ---------- ---------- -----MYPEE S-RGSGGVAT
Q9YH33|N.TILAPIA_ ---------- ---------- ---------- ---------- -----MYPEE S-RGSGGVAT
P50241|M.FISH____ MSKRQSSVQI RQLFGPALRS RISPASSELE TLSPPRLSPR DPLGDMYPEE S-RGSGGVAA
P16058|R.TROUT___ MLVRQSHTQI SKPLGAPLRS RTTLESHVIS PPKLSPQQPT TPNSNMYPEE T-RGGGGAAA
--------------------------------------------------------------------:*-.---------.-

Q9TV98|HORSE_____ VYDYPEGAAY DFNAAAAAS- ----ASVYGQ SGLAYGPGSE AAAFGANGLG GFPPLNSVSP
Q29040|PIG_______ VYNYPEGAAY DFNAAAAAS- ----APVYGQ SGLAYGPGSE AAAFGANGLG GFQPLNSVSP
P03372|HUMAN_____ VYNYPEGAAY EFNAAAAAN- ----AQVYGQ TGLPYGPGSE AAAFGSNGLG GFPPLNSVSP
P19785|MOUSE_____ VFNYPEGAAY EFNAAAAAAA A-ASAPVYGQ SGIAYGPGSE AAAFSANSLG AFPQLNSVSP
P06211|RAT_______ VFNYPEGAAY EFNAAAAAAA AGASAPVYGQ SSITYGPGSE AAAFGANSLG AFPQLNSVSP
Q9QZJ5|G.HAMPSTER MFNYPEGAAY EFNAATAP-- ----APVYGQ TGIAYGSGSE ATAFGSNSLG LFPQLNSVSP
P06212|CHICK_____ VFNYPEGATY DFGTT----- ----APVYGS TTLSYAPTSE S--FGSSSLA GFHSLNNVPP
Q91250|Z.FINCH___ VFNYPEGATY DFGTT----- ----APVYSS TTLSYAPTSE S--FGSSSLA GFHSLNSVPP
P81559|XENOPUS___ IFNYPEGTTY DFAAA-A--- ----APVYSS ASLSYAASSE T--FGSSSLT GLHTLNNVPP
Q9YHZ7|CATFISH___ TAHYLDG-TF NYT------- ---TNPDATN SSVDYYSVAP E-PQ----EE NLQPLPNGSS
P57717|ZEBRAFISH_ SVNYLDG-AY EYPNPTQAF- --GTSSPAEP ASVGYYPAPP D-PH----EE HLQTLGGGSS
Q9PVZ9|G.SEABREAM -VDFLEG-TY DYAAPTP--- --APTPLYSH STPGYYSAPL D-AHGPPSDG SLQSLGSGPN
O42132|R.SEABREAM -VDFLEG-TY DYAAPTP--- --APTPLYSH STPGYYSAPL D-AHGPPSDG SLQSLGSGPN
P50240|I.TILAPIA_ -VDFLEG-LM TMTAPTP--- --APTPLYSH STTGCYSAPL D-AHGPLSDG SLQSLGSGPT
Q9YH33|N.TILAPIA_ -VDFLEG-TY DYAAPTP--- --APTPLYSH STTGCYSAPL D-AHGPLSDG SLQSLGSGPT
P50241|M.FISH____ -VDFLEG-TY DYAAPNP--- --ATTPLYSQ SSTGYYSAPL E-TNGPPSEG SLQSLGSGPT
P16058|R.TROUT___ -FNYLDG-GY DYTAPAQ--- --GPAPLY-- ----YSTTPQ D-AHGPPSDG SMQSLGSSPT
--------------------.:-:*--- ---------- ---------- ------. . ----------- -:--* . .

Q9TV98|HORSE_____ SQLMLLHPPP ----QLSPYL -HPPGQQ--- --VPYYLENE PSGYSVCEAG PQAFYRPNAD
Q29040|PIG_______ SPLVLLHPPP ----QLSPFL -HPHGQQ--- --VPYYLENE PSGYAVREAG PPAFYRPNSD
P03372|HUMAN_____ SPLMLLHPPP ----QLSPFL -QPHGQQ--- --VPYYLENE PSGYTVREAG PPAFYRPNSD
P19785|MOUSE_____ SPLMLLHPPP ----QLSPFL -HPHGQQ--- --VPYYLENE PSAYAVRDTG PPAFYRSNSD
P06211|RAT_______ SPLMLLHPPP ----HVSPFL -HPHGHQ--- --VPYYLENE PSAYAVRDTG PPAFYRSNSD
Q9QZJ5|G.HAMPSTER SPLMLLHPPP P---QLSPFL -HPHGQQ--- --VPYYLENE PSAYAVRDSG PPAFYRSNSD
P06212|CHICK_____ SPVVFLQTAP ----QLSPFI -HHHSQQ--- --VPYYLENE QGSFGMREAA PPAFYRPSSD
Q91250|Z.FINCH___ SPVVFLQTAP ----HWSPFI -HHHSQQ--- --VPYYLEND QGSFGMREAA PPAFYRPNSD
P81559|XENOPUS___ SPVVFLAKLP ----QLSPFI -HHHGQQ--- --VPYYLESE QGTFAVREAA PPTFYRSSSD
Q9YHZ7|CATFISH___ SPPVFVPSSP ----QLSPFL GHPPAGQHTA QQVPYYLEPS GTSIYRSSVL ASAGSRV---
P57717|ZEBRAFISH_ SPLMFAPSSP ----QLSPYL SHHGGHHTTP HQVSYYLDSS SSTVYRSSVV SSQQAAVGLC
Q9PVZ9|G.SEABREAM SPLVFVPSSP ----HLSPFM -QPANHH--- -----YLETT STPIY--SVP SSQHSVSR--
O42132|R.SEABREAM SPLVFVPSSP ----RLSPFM -HPPTHH--- -----YLETT STPVYRSSVP SSQQSVSR--
P50240|I.TILAPIA_ SPLVFVPSSP ----RLSPFM -HPPSHH--- -----YLETT STPVYR---- SSHQPVPR--
Q9YH33|N.TILAPIA_ SPLVFVPSSP ----RLSPFM -HPPSHH--- -----YLETT STPVYR---- SSHQPVPR--
P50241|M.FISH____ SPLVFVPSSP ----RLSPFM -HPPSHH--- -----YLETT STPVYR---- SSHQGASR--
P16058|R.TROUT___ GPLVFVSSSP QLSPQLSPFL -HPPSHHGLP SQS-YYLETS STPLYRSSVV TNQLSASE--
------------------. -:: ---* --- : **:: -:--- :--- ---- **: - ---------- .

Q9TV98|HORSE_____ NRRQGGRERL ASSGDKGSMA ----MESA-- ------KETR YCAVCNDYAS GYHYGVWSCE
Q29040|PIG_______ NRRQGGRERL ASTSDKGSMA ----MESA-- ------KETR YCAVCNDYAS GYHYGVWSCE
P03372|HUMAN_____ NRRQGGRERL ASTNDKGSMA ----MESA-- ------KETR YCAVCNDYAS GYHYGVWSCE
P19785|MOUSE_____ NRRQNGRERL SSSNEKGNMI ----MESA-- ------KETR YCAVCNDYAS GYHYGVWSCE
P06211|RAT_______ NRRQNGRERL SSSSEKGNMI ----MESA-- ------KETR YCAVCNDYAS GYHYGVWSCE
Q9QZJ5|G.HAMPSTER NRRQSGRERL SSSSEKGSMA ----MESV-- ------KETR YCAVCNDYAS GYHYGVWSCE
P06212|CHICK_____ NRRHSIRERM SSTNEKGSLS ----MEST-- ------KETR YCAVCNDYAS GYHYGVWSCE
Q91250|Z.FINCH___ NRRHSIRERM SSANEKGSLS ----MEST-- ------KETR YCAVCNDYAS GYHYGVWSCE
P81559|XENOPUS___ NRRQSGRERM SSANDKGPPS ----MEST-- ------KETR YCAVCSDYAS GYHYGVWSCE
Q9YHZ7|CATFISH___ -ELCSAPGRQ DVYTAVGASG P--SGASGPS GAIGLVKEIR YCSVCSDYAS GYHYGVWSCE
P57717|ZEBRAFISH_ EELCSATDRQ ELYTGSRAAG ---GFDSG-- ------KETR FCAVCSDYAS GYHYGVWSCE
Q9PVZ9|G.SEABREAM EDQCGTSDDS YSVGESGAGA GAAGFEMA-- ------KEMR FCAVCSDYAS GYHYGVWSCE
O42132|R.SEABREAM EDQCGTSDDS YSVGESGAGA LAAGFEIA-- ------KEMR FCAVCSDYAS GYHYGVWSCE
P50240|I.TILAPIA_ EDQCGTRDEA YSVGELGAGA G--GFEIT-- ------KNTR FCAVCSDYAS GYHYGVWSCE
Q9YH33|N.TILAPIA_ EDQCGTRDEA YSVGELGAGA G--GFEMT-- ------KDTR FCAVCSDYAS GYHYGVWSCE
P50241|M.FISH____ EDQCGSREDT CSLGELGAGA GAGGFEMA-- ------KDTR FCAVCSDYAS GYHYGVWSCE
P16058|R.TROUT___ EKLCIASDRQ QSYSAAGSGV R--VFEMA-- ------NETR YCAVCSDFAS GYHYGVWSCE
---------------------------- ---------- ---------- ------:: * :*:**.*:** **********

Q9TV98|HORSE_____ GCKAFFKRSI QGHNDYMCPA TNQCTIDKNR RKSCQACRLR KCYEVGMMKG GIRKDRRGGR
Q29040|PIG_______ GCKAFFKRSI QGHNDYMCPA TNQCTIDKNR RKSCQACRLR KCYEVGMMKG GIRKDRRGGR
P03372|HUMAN_____ GCKAFFKRSI QGHNDYMCPA TNQCTIDKNR RKSCQACRLR KCYEVGMMKG GIRKDRRGGR
P19785|MOUSE_____ GCKAFFKRSI QGHNDYMCPA TNQCTIDKNR RKSCQACRLR KCYEVGMMKG GIRKDRRGGR
P06211|RAT_______ GCKAFFKRSI QGHNDYMCPA TNQCTIDKNR RKSCQACRLR KCYEVGMMKG GIRKDRRGGR
Q9QZJ5|G.HAMPSTER GCKAFFKRSI QGHNDYMCPA TNQCTIDKNR RKSCQACRLR KCYEVGMMKG GIRKDRRGGR
P06212|CHICK_____ GCKAFFKRSI QGHNDYMCPA TNQCTIDKNR RKSCQACRLR KCYEVGMMKG GIRKDRRGGE
Q91250|Z.FINCH___ GCKAFFKRSI QGHNDYMCPA TNQCTIDKNR RKSCQACRLR KCYEVGMMKG GIRKDRRGGR
P81559|XENOPUS___ GCKAFFKRSI QGHNDYMCPA TNQCTIDKNR RKSCQACRLR KCYEVGMMKG GIRKDRRGGR
Q9YHZ7|CATFISH___ GCKAFFKRSI QGHNDYVCPA TNQCTIDRNR RKSCQACRLR KCYEVGMMKG GFRKER-GGR
P57717|ZEBRAFISH_ GCKAFFKRSI QGHNDYVCPA TNQCTIDRNR RKSCQACRLR KCYEVGMMKG GIRKDR-GGR
Q9PVZ9|G.SEABREAM GCKAFFKRSI QGHNDYMCPA TNQCTIDRNR RKSCQACRLR KCYEVGMMKG GVRKDR-G-R
O42132|R.SEABREAM GCKAFFKRSI QGHNDYMCPA TNQCTIDRNR RKSCQACRLR KCYEVGMMKG GMRKDR-G-R
P50240|I.TILAPIA_ GCKAFFKRSI QGHNDYMCPA TNQCTIDKNR RKSCQACRLR KCYEVGMMKG GMRKDR-G-R
Q9YH33|N.TILAPIA_ GCKAFFKRSI QGHNDYMCPA TNQCTIDKNR RKSCQACRLR KCYEVGMMKG GMRKDR-G-R
P50241|M.FISH____ GCKAFFKRSI QGHNDYMCPA TNQCTIDRNR RKSCQACRLR KCYEVGMMKG GVRKDR-I-R
P16058|R.TROUT___ GCKAFFKRSI QGHNDYMCPA TNQCTMDRNR RKSCQACRLR KCYEVGMVKG GLRKDR-GGR
------------------********** ******:*** *****:*:** ********** *******:** *.**:*-- .

Q9TV98|HORSE_____ MLKHKRQRDD -GEGRNEAGP SGDRRPANFW PSPLLIKHTK KI------SP VLSLTAEQMI
Q29040|PIG_______ MLKHKRQRDD -GEGRNEAVP PGDMRSANLW PSPLLIKHTK KN------SP VLSLTADQMI
P03372|HUMAN_____ MLKHKRQRDD -GEGRGEVGS AGDMRAANLW PSPLMIKRSK KN------SL ALSLTADQMV
P19785|MOUSE_____ MLKHKRQRDD -LEGRNEMGA SGDMRAANLW PSPLVIKHTK KN------SP ALSLTADQMV
P06211|RAT_______ MLKHKRQRDD -LEGRNEMGT SGDMRAANLW PSPLVIKHTK KN------SP ALSLTADQMV
Q9QZJ5|G.HAMPSTER MLKHKRQRDD -LEGRNDMGP SGDMRATNLW PSPLVIKHTK KN------SP ALSLTADQMV
P06212|CHICK_____ MMKQKRQREE -QDSRNGEAS STELRAPTLW TSPLVVKHNK KN------SP ALSLTAEQMV
Q91250|Z.FINCH___ VMKQKRQREE -QDSRNGEAS STELRAPTLW ASPLVVKHNK KN------SP ALSLTAEQMV
P81559|XENOPUS___ LLKHKRQKEE -QEQKNDVDP S-EIRTASIW VNPSVK--SM KL------SP VLSLTAEQLI
Q9YHZ7|CATFISH___ IIKHNRRPSG -LKERERGYS KAQSGSDVRE ALPQ--DGQS SSGIGGGVAD VVCMSPEQVL
P57717|ZEBRAFISH_ SVRRERRRSS -NEDRDKSSS DQCSRAGVRT TGPQ--DKRK KR--SGGVVS TLCMPPDQVL
Q9PVZ9|G.SEABREAM VLRRDKRRTG -TSDRDKASK GLEHRTAPPQ DRRK--HISS SAGGGGGKSS VISMPPDQVL
O42132|R.SEABREAM VLRRDKQRTG -TSDRDKASK GLEHRTAPPQ DRRK--HISS SAGGGGGKSS MISMPPDQVL
P50240|I.TILAPIA_ VLRREKH--G -PAQR-QTSQ NLPTHKASPQ DGRKRAMSSS STSGPGGRSS LNNMPPDQVL
Q9YH33|N.TILAPIA_ VLRREKR--R -ACDRDKPAK DLPHTRASPQ DGRKRAMSSS STSGGGGRSS LNNMPPDQVL
P50241|M.FISH____ ILRRDKRRTG -VGDGDKVVK GQEHKTVH-Y DGRKRSSTGG GGGGGGGRLS VTSIPPEQVL
P16058|R.TROUT___ VLRKDKRYCG PAGDREKPYG DLEHRTAPPQ DGGR-NSSSS LNGGGGWRGP RITMPPEQVL
-------------------:::.:: -- ---------- ---------- ---------- ---------- ---:..:*::

Q9TV98|HORSE_____ SALLDAEPPV LYSEYDATRP FNEASMMGLL TNLADRELVH MINWAKRVPG FVDLSLHDQV
Q29040|PIG_______ SALLEAEPPI IYSEYDPTRP LSEASMMGLL TNLADRELVH MINWAKRVPG FLDLSLHDQV
P03372|HUMAN_____ SALLDAEPPI LYSEYDPTRP FSEASMMGLL TNLADRELVH MINWAKRVPG FVDLTLHDQV
P19785|MOUSE_____ SALLDAEPPM IYSEYDPSRP FSEASMMGLL TNLADRELVH MINWAKRVPG FGDLNLHDQV
P06211|RAT_______ SALLDAEPPL IYSEYDPSRP FSEASMMGLL TNLADRELVH MINWAKRVPG FGDLNLHDQV
Q9QZJ5|G.HAMPSTER SALLDAEPPL IYSEYDPSRP FSEASMMGLL TNLADRELVH MINWAKRVPG FGDLNLHDQV
P06212|CHICK_____ SALLEAEPPI VYSEYDPNRP FNEASMMTLL TNLADRELVH MINWAKRVPG FVDLTLHDQV
Q91250|Z.FINCH___ SALLEAEPPL VYSEYDPNRP FNEASMMTLL TNLADRELVH MINWAKRVPG FVDLTLHDQV
P81559|XENOPUS___ SALMEAEAPI VYSEHDSTKP LSEASMMTLL TNLADRELVH MINWAKRVPG FVDLTLHDQV
Q9YHZ7|CATFISH___ LLLLRAEPPT LCSRQKHSRP YSELTIMSLL TNMADRELVH MIAWAKKVPG FQDLSLHDQV
P57717|ZEBRAFISH_ LLLLGAEPPA VCSRQKHSRP YTEITMMSLL TNMADKELVH MIAWAKKVPG FQDLSLHDQV
Q9PVZ9|G.SEABREAM LLLRGAEPPM LCSRQKVNRP YTEVTVMTLL TSMADKELVH MIAWAKKLPG FLQLSLHDQV
O42132|R.SEABREAM LLLQGAEPPM LCSRQKLNRP YTEVTMMTLL TSMADKELVH MIAWAKKLPG FLQLSLHDQV
P50240|I.TILAPIA_ LLLQGAEPPI LCSRQKMSRP YTEVTIMTLL TSMADKELVH MITWAKKLPG FLQLSLHDQV
Q9YH33|N.TILAPIA_ LLLQGAEPPI LSSRQKMSRP YTEVTIMTLL TSMADKELVH MITWAKKLPG FLQLSLHDQV
P50241|M.FISH____ LLLQGAEPPI LCSRQKLSRP YTEVTMMTLL TSMADKELVH MIAWAKKLPG FLQLSLHDQV
P16058|R.TROUT___ FLLQGAEPPA LCSRQKVARP YTEVTMMTLL TSMADKELVH MIAWAKKVPG FQELSLHDQV
--------------------* -**.* -: *. . -:* -.* ::* ** *.:**:**** ** ***::** * :*.*****

Q9TV98|HORSE_____ HLLECAWLEI LMIGLVWRSM EHPGKLLFAP NLLLDRNQGK CVEGMVEIFD MLLATSSRLR
Q29040|PIG_______ HLLECAWLEI LMIGLVWRSM EHPGKLLFAP NLLLDRNQGK CVEGMVEIFD MLLATSSRFR
P03372|HUMAN_____ HLLECAWLEI LMIGLVWRSM EHPGKLLFAP NLLLDRNQGK CVEGMVEIFD MLLATSSRFR
P19785|MOUSE_____ HLLECAWLEI LMIGLVWRSM EHPGKLLFAP NLLLDRNQGK CVEGMVEIFD MLLATSSRFR
P06211|RAT_______ HLLECAWLEI LMIGLVWRSM EHPGKLLFAP NLLLDRNQGK CVEGMVEIFD MLLATSSRFR
Q9QZJ5|G.HAMPSTER HLLECAWLEI LMIGLIWRSM EHPGKLLFAP NLLLDRNQGK CVEGMVEIFD MLLATSARFR
P06212|CHICK_____ HLLECAWLEI LMIGLVWRSM EHPGKLLFAP NLLLDRNQGK CVEGMVEIFD MLLATAARFR
Q91250|Z.FINCH___ HLLECAWLEI LMIGLVWRSM EHPGKLLFAP NLLLDRNQGK CVEGMVEIFD MLLATAARFR
P81559|XENOPUS___ HLLECAWLEI LMVGLIWRSV EHPGKLSFAP NLLLDRNQGR CVEGLVEIFD MLVTTATRFR
Q9YHZ7|CATFISH___ QLLESSWLEI LMIGLIWRSI YTPGKLIFAQ DLILDKSEGE CVEGMAEIFD MLLATVARFR
P57717|ZEBRAFISH_ QLLESSWLEV LMIGLIWRSI HSPGKLIFAQ DLILDRSEGE CVEGMAEIFD MLLATVARFR
Q9PVZ9|G.SEABREAM QLLESSWLEV LMIGLIWRSI HCPGKLIFAQ DLILDRSEGD CVEGMAEIFD MLLATASRFR
O42132|R.SEABREAM QLLESSWLEV LMIGLIWRSI HCPGKLIFAQ DLILDRSEGD CVEGMAEIFD MLLATASRFR
P50240|I.TILAPIA_ LLLESSWLEV LMIGLIWRSI QCPGKLIFEE DLILDRNEGT CVEGMAEIFD MLLATV-RFR
Q9YH33|N.TILAPIA_ LLLESSWLEV LMIGLIWRSI QCPGKLIFAQ DLILDRNEGT CVEGMAEIFD MLLATASRFR
P50241|M.FISH____ LLLESSWLEV LMIGLIWRSI HCPGKLIFAQ DLILDRNEGD CVEGMTEIFD MLLATASRFR
P16058|R.TROUT___ QLLESSWLEV LMIGLIWRSI HCPGKLIFAQ DLILDRSEGD CVEGMAEIFD MLLATVSRFR
-------------------***.:***: **:**:***: - **** * - :*:**:.:* -****:.**** **::* -*:*

Q9TV98|HORSE_____ MMNLQGEEFV CLKSIILLNS GVYTFLSSTL KSLEEKDHIH RVLDKMTDTL IHLMAKAGLT
Q29040|PIG_______ MMNLQGEEFV CLKSIILLNS GVYTFLSSTL KSLEEKDHIH RVLDKITDTL IHLMAKAGLT
P03372|HUMAN_____ MMNLQGEEFV CLKSIILLNS GVYTFLSSTL KSLEEKDHIH RVLDKITDTL IHLMAKAGLT
P19785|MOUSE_____ MMNLQGEEFV CLKSIILLNS GVYTFLSSTL KSLEEKDHIH RVLDKITDTL IHLMAKAGLT
P06211|RAT_______ MMNLQGEEFV CLKSIILLNS GVYTFLSSTL KSLEEKDHIH RVLDKINDTL IHLMAKAGLT
Q9QZJ5|G.HAMPSTER MMDLQGEEFV CLKSIILLNS GVYTFLSSTL KSLEEKDHIH RVLDKITDTL IHLMAKAGLT
P06212|CHICK_____ MMNLQGEEFV CLKSIILLNS GVYTFLSSTL KSLEERDYIH RVLDKITDTL IHLMAKSGLS
Q91250|Z.FINCH___ MMNLQGEEFV CLKSIILLNS GVYTFLSSTL KSLEEKDYIH RVLDKITDTL IHLMAKSGLS
P81559|XENOPUS___ MMRLRGEEFI CLKSIILLNS GVYTFLSSTL ESLEDTDLIH IILDKIIDTL VHFMAKSGLS
Q9YHZ7|CATFISH___ TLKLKSEEFV CLKAIILLNS GAFSFCSSPV EPLRDGFMVQ CMMDNITDAL IYYISQSGIS
P57717|ZEBRAFISH_ SLKLKLEEFV CLKAIILINS GAFSFCSSPV EPLMDNFMVQ CMLDNITDAL IYCISKSGAS
Q9PVZ9|G.SEABREAM MLKLKPEEFV CLKAIILLNS GAFSFCTGTM EPLHDSAAVQ NMLDTITDAL IHHINQSGCS
O42132|R.SEABREAM MLKLKPEEFV CLKAIILLNS GAFSFCTGTM EPLHDGAAVQ NMLDTITDAL IHHINQSGCS
P50240|I.TILAPIA_ VLKLKPEEFV CLKAIILLNS GAFSFCTGTM EPLHDSVAVQ HMLDTITDAL IFHISHFGCS
Q9YH33|N.TILAPIA_ VLKLKPEEFV CLKAIILLNS GAFSFCTGTM EPLHDSAAVQ HMLDTITDAL IFHISHLGCS
P50241|M.FISH____ VLKLKPEEFV CLKAIILLNS GAFSFCTGTM EPLHNSAAVQ SMLDTITDAL IHYISQSGYL
P16058|R.TROUT___ MLKLKPEEFV CLKAIILLNS GAFSFCSNSV ESLHNSSAVE SMLDNITDAL IHHISHSGAS
-------------------: *: ***: ***:***:** *.::* :..: :.* :-- :. -::*.: *:* :. : : *

Q9TV98|HORSE_____ LQQ-HRRLAQ LLLILSHIRH MSNKGMEHLY SMKCKNVVPL YDLLLEMLDA HRLHAPANHG
Q29040|PIG_______ LQQQHRRLAQ LLLILSHFRH MSNKGMEHLY NMKCKNVVPL YDLLLEMLDA HRLHAPTNLG
P03372|HUMAN_____ LQQQHQRLAQ LLLILSHIRH MSNKGMEHLY SMKCKNVVPL YDLLLEMLDA HRLHAPTSRG
P19785|MOUSE_____ LQQQHRRLAQ LLLILSHIRH MSNKGMEHLY NMKCKNVVPL YDLLLEMLDA HRLHAPASRM
P06211|RAT_______ LQQQHRRLAQ LLLILSHIRH MSNKGMEHLY NMKCKNVVPL YDLLLEMLDA HRLHAPASRM
Q9QZJ5|G.HAMPSTER LQQQHRRLAQ LLLILSHIRH MSNKGMEHLY NMKCKNVVPF YDLLLEMLDA HRLHTPVSRM
P06212|CHICK_____ LQQQHRRLAQ LLLILSHIRH MSNKGMEHLY NMKCKNVVPL YDLLLEMLDA HRLHAPAARS
Q91250|Z.FINCH___ LQQQHRRLAQ LLLILSHIRH MSNKGMEHLY NMKCKNVVPL YDLLLEMLDA HRLHAPAARS
P81559|XENOPUS___ LQQQQRRLAQ LLLILSHIRH MSNKGMEHLY SMKCKNVVPL YDLLLEMLDA HRIHTPKDK-
Q9YHZ7|CATFISH___ VQLQSRRQAQ LLLLLSHIRH MSYKGMEHLY SMKCKNKVPL YDLLLEMLDA HRLRPLGKVP
P57717|ZEBRAFISH_ LQLQSRRQAQ LLLLLSHIRH MSNKGMEHLY RMKCKNRVPL YDLLLEMLDA QRFQSSGKVQ
Q9PVZ9|G.SEABREAM AQQQSRRQAQ LLLLLSHIRH MSNKGMEHLY SMKCKNKVPL YDLLLEMLDA HRVHRPDRPA
O42132|R.SEABREAM AQQQSRRQAQ LLLLLSHIRH MSNKGMEHLY SMKCKNKVPL YDLLLEMLDA HRIHRADRPA
P50240|I.TILAPIA_ AQQQSRRQAQ LLLLLSHIRH MSNKGMEHLY SMKCKNKVPL YDLLLEMLDA HRIHRPVKPS
Q9YH33|N.TILAPIA_ AQQQSRRQAQ LLLLLSHIRH MSNKGMEHLY SMKCKNKVPL YDLLLEMLDA HRIHRPVKPF
P50241|M.FISH____ AQEQARRQAQ LLLLLSHIRH MSNKGMEHLY SMKCKNKVPL YDLLLEMLDA HRLHHPVRAP
P16058|R.TROUT___ VQQQPRRQAQ LLLLLSHIRH MSNKGMEHLY SIKCKNKVPL YDLLLEMLDG HRLQSPGKVA
-------------------* --:* ** ***:***:** ** ******* -:**** **: *********. :*.:

Q9TV98|HORSE_____ GAPMEETNQS QLATTGS--- ---------- --TSPHSMQT YYITG----- -----EAEGF
Q29040|PIG_______ GPPPEDMSQS QLATSGS--- ---------- --TPSHSLQM YYITG----- -----EAENF
P03372|HUMAN_____ GASVEETDQS HLATAGS--- ---------- --TSSHSLQK YYITG----- -----EAEGF
P19785|MOUSE_____ GVPPEEPSQT QLATTSS--- ---------- --TSAHSLQT YYIPP----- -----EAEGF
P06211|RAT_______ GVPPEEPSQS QLTTTSS--- ---------- --TSAHSLQT YYIPP----- -----EAEGF
Q9QZJ5|G.HAMPSTER GVSPEEPSQS QLTTTNS--- ---------- --TSSHSLQT YYIPS----- -----EAESF
P06212|CHICK_____ AAPMEEENRN QLTTAP---- ---------- --ASSHSLQS FYINSK---- -----EEESM
Q91250|Z.FINCH___ AAPMEEENRS QLTTAS---- ---------- --ASSHSLQS FYINSK---- -----EEENM
P81559|XENOPUS___ TTTQEEDSRS PPTTTVN--- ---------- --GASPCLQP YYTNT----- -----EEVSL
Q9YHZ7|CATFISH___ RIWADRVSSS PTTTATT--- ---------P TTNTTTTTTT TTHHPSNGS- ----TCPADL
P57717|ZEBRAFISH_ RVWSQ----- ---SEKN--- ---------P PSTPTTSSSS SNNSPRGG-- ------AAAI
Q9PVZ9|G.SEABREAM ETWSQADREP LFTSRNSSSS SGGGGG-GSS SAGSTSGPQV NLESP----- ----TGPGVL
O42132|R.SEABREAM ETWSQADREP PFTSRNSSGG GGGGGG-GSS SAGSTSGPRV SHESP----- ----TSPGVL
P50240|I.TILAPIA_ QSWSQGDRDS PTASSTSSRG GGGGDDEGAS SAGSSSGPQG SHESPRRENL SRAPKGPGVL
Q9YH33|N.TILAPIA_ QSWSQGDRDS PTASSTSSSG GGGGDDEGAS SAGSSSGPQG SHESPRRENL SRAPTGPGVL
P50241|M.FISH____ QSLSQVDRDP PSTSS----- GGGG-----I APGSISASRG RIESP----- SRGPFAPSVL
P16058|R.TROUT___ QAGEQTEGPS TTTTT----- S-TG-----S SIGPMRGSQD THIRS----- ----PGSGVL
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