Welcome to Project HOPE!
Project HOPE is an easy-to-use webserver that analyses the
structural effects of your mutation of interest. The server allows you
to submit a protein sequence and the mutation. Project HOPE will then
collect and combine available information from a series of webservers
and databases and will produce a mutation report complete with
results, figures and animations.
Where available Project HOPE will use the 3D structure of the protein but the server can also build a homology model if necessary. Other information sources include the Uniprot database and a series of DAS prediction servers. If you want to read more about the procedure used by Project HOPE's, have a look at the methods page.